Maternal and neonatal deaths remain a concern in the Cameroon health system. The poor maternal and neonatal health indicators have multiple factors ranging from poor infrastructure, existing knowledge and skill gap in MNH-QoC standards to cultural practices. However, the prevailing COVID-19 pandemic has widened the gap between the quality of maternal and child health services expected and what is actually provided at the facility and community levels. Training, regular supervision, monitoring and on-site mentoring are key ways to bridge knowledge gap and institute a system to strengthen maternal and newborn health care at sub-national levels. However, the aforementioned interventions have to be informed by real time evidence.